Acute-on-chronic liver failure in children

Table 4 Modified chronic liver failure–sequential organ failure assessment score

Organ/systems	0	1	2	3	4
Liver (bilirubin, mg/dL)	< 1.2	≥ 1.2 to < 2.0	≥ 2.0 to < 6.0	≥ 6.0 to < 12.0	≥ 12.0
Kidney (creatinine, rise from baseline)	< 1.5 ×	1.5 to ≤ 2.0 ×	> 2.0 to ≤ 3 ×	> 3 ×	Need for RRT
Cerebral (HE grade)	0	I	II	III	IV
Coagulation (INR)	< 1.1	≥ 1.1 to ≤ 1.25	> 1.25 to < 1.5	≥ 1.5 to ≤ 2.5	> 2.5
Circulation (systolic BP)	Normal for age	< 5th centile for age	NE < 0.5 µg/kg/min	NE > 0.5 µg/kg/min	NE > 0.5 µg/kg/min and 2nd inotrope
Lungs
PaO/FiO2	> 400	> 300 to ≤ 400	> 200 to ≤ 300	> 100 to ≤ 200	≤ 100

BP: Blood pressure; HE: Hepatic encephalopathy; INR: International normalized ratio; NE: Norepinephrine; PaO2: Partial pressure of arterial oxygen; FiO2: Fraction of inspired oxygen; RRT: Renal replacement therapy.