Acute-on-chronic liver failure in children

Table 2 Chronic liver failure–sequential organ failure assessment score

Organ/systems	0	1	2	3	4
Liver (bilirubin, mg/dL)	< 1.2	≥ 1.2 to < 2.0	≥ 2.0 to < 6.0	≥ 6.0 to < 12.0	≥ 12.0
Kidney (creatinine, mg/dL)	< 1.2	≥ 1.2 to < 2.0	≥ 2.0 to < 3.5	≥ 3.5 to < 5.0(or RRT)	≥ 5.0(or RRT)
Cerebral (HE grade)	No HE	I	II	III	IV
Coagulation (INR)	< 1.1	≥ 1.1 to < 1.25	≥ 1.25 to < 1.5	≥ 1.5 to < 2.5	≥ 2.5 or platelet < 20 × 109 /L
Circulation (mean arterial pressure, mm Hg)	≥ 70	< 70	Dopamine ≤ 5 or dobutamine or terlipressin(µg/kg/min)	Dopamine > 5 or E ≤ 0.1 or NE ≤ 0.1(µg/kg/min)	Dopamine > 15 or E > 0.1 or NE > 0.1(µg/kg/min)
Lungs
PaO/FiO2	> 400	> 300 to ≤ 400	> 200 to ≤ 300	> 100 to ≤ 200	≤ 100
or SpO2/FiO2	> 512	> 357 to ≤ 512	> 214 to ≤3 57	< 89 to ≤ 214	≤ 89

BP: Blood pressure; E: Epinephrine; FiO2: Fraction of inspired oxygen; HE: Hepatic encephalopathy; INR: International normalized ratio; NE: Norepinephrine; PaO2: Partial pressure of arterial oxygen; RRT: Renal replacement therapy; SpO2: Pulse oximetric saturation.