Integrative analysis of layers of data in hepatocellular carcinoma reveals pathway dependencies

doi:10.4254/wjh.v13.i1.94

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Jan 27, 2021 (publication date) through Nov 4, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jan 27, 2021; 13(1): 94-108
Published online Jan 27, 2021. doi: 10.4254/wjh.v13.i1.94

Table 3 Modulation of the 9 dysregulated genes associated with the 3 common dysregulated pathways (EGFR, epidermal growth factor, β1-integrin and axon guidance) identified in the 19 hepatocellular carcinoma gene expression papers. Their genetic alteration in hepatocellular carcinoma and their mechanism in cancer are reported

Gene	Modulation in the 19 HCC papers	PMID	Mutation in HCC (PMID)	Role in cancer (PMID)
COL2A1	Up (2/19)	23800896/25666192	(rs3917) polymorphism is associated with higher risk of HCC (21665180)	COL2A1 promotes migration in HCC (29858962)
FGA	Down (9/19)	21320499/23800896/25093504/25536056/25141867/25376302/25666192/25645722/25666192	Deleted in HCC patients (27511114)	FGA is a positive predictor of survival in gastric cancer patients (15756001)
FGG	Down 8/19	21320499/23800896/25093504/25536056/25141867/25376302/25645722/24498002	Allelic loss (16980951)	FGG is involved in amino acid and redox metabolism pathway in HCC (28089356)
LAMC1	Up (4/19)	23800896/25536056/25141867/25645722	Not identified	LAMC1 promotes tumor cell invasion and migration in HCC (28928891)
CDK5	Up (2/19)	25141867/25376302	Not identified	CDK5 promotes proliferation in HCC (29312535)
EPHB1	Down (2/19)	23800896/25141867	Missense mutation (19469653)	EPHB1 inhibits cell migration(22242939)
RPS6KA3	Up 1/19	25141867	Somatic mutation and copy number variations (22561517)	RPS6KA3 increases cell proliferation (15833840)
EGFR	Down (2/19)	19098997/25141867	Missense mutation (26436086)	EGFR promotes cell adhesion (31465839)
ITGB1	Up (1/19)	25141867	Somatic number variations (24512821)	ITGB1 promotes migration (30664185)

HCC: Hepatocellular carcinoma.

Citation: Bhat M, Pasini E, Pastrello C, Rahmati S, Angeli M, Kotlyar M, Ghanekar A, Jurisica I. Integrative analysis of layers of data in hepatocellular carcinoma reveals pathway dependencies. World J Hepatol 2021; 13(1): 94-108
URL: https://www.wjgnet.com/1948-5182/full/v13/i1/94.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i1.94