Integrative analysis of layers of data in hepatocellular carcinoma reveals pathway dependencies

Table 2 Prognostic value of the 9 dysregulated genes associated with the 3 common dysregulated pathways (EGFR, epidermal growth factor, β1-integrin and axon guidance) among the 4 types of data in obtained with KMplotter

Gene	Modulation in the 19 HCC papers	Probe-ID	HR	CI	Log-Rank P value	Median survival low (mo)	Median survival high (mo)	Estradiol gene modulation predicted by CTD
COL2A1	Up	1280	1.49	1.05-2.11	0.0229	61.7	54.1	N/A
FGA	Down	2243	0.52	0.35-0.77	0.0009	49.7	70.5	+
FGG	Down	2266	0.56	0.39-0.79	0.0009	38.3	70.5	+
LAMC1	Up	3915	1.43	0.98-2.09	0.06	56.5	38.3	N/A
CDK5	Up	1020	1.85	1.22-2.81	0.0035	81.9	6.2	N/A
EPHB1	Down	2047	0.72	0.048-1.08	0.1135	54.1	70.5	N/A
RPS6KA3	Up	6197	1.2	0.8-1.78	0.3743	54.1	56.5	-
EGFR	Down	1956	0.61	0.43-0.89	0.0085	31	70.5	+
ITGB1	Up	3688	1.37	0.95-1.97	0.0924	82.9	49.7	N/A

CTD based prediction identified Estradiol to efficiently affect the expression of the 4/9 genes based on their hazard ratios values. HR: Hazard ratios; HCC: Hepatocellular carcinoma; CI: Confidence interval; N/A: Not applicable.