N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure

Figure 9 Delayed administration of N-acetylcysteine/glycyrrhizin combination increased mice survival following acetaminophen-induced liver injury compared to glycyrrhizin or N-acetylcysteine alone. Comparison of cumulative probability mice survival after acetaminophen (APAP) challenge (10 mice in each group). Mice were treated with glycyrrhizin (GL, 200 mg/kg), N-acetylcysteine (NAC, 150 mg/kg) or by a NAC/GL combination. Treatment was co-administered with APAP or administered 2 h or 6 h after APAP injection. Mice were followed for 172 h. Mice were euthanized when they became moribund per the criteria of lack of response to stimuli or lack of righting reflex. Kaplan-Meier survival curves were compared using log-rank test. ^cP < 0.01, ^dP < 0.001 vs APAP. Experiments were reproduced three times.