Sofosbuvir plus ribavirin is tolerable and effective even in elderly patients 75-years-old and over

Table 2 Comparison of pre-treatment factors between patients ≥ 75-years-old and < 75-years-old

Factors	Patients ≥ 75-yr-old, n = 83	Patients < 75-yr-old, n = 182	P value
Age in yr	79 (75-86)	64 (17-74)	< 0.001
Sex as male/female	42/41 (51%/49%)	108/74 (59%/41%)	0.183
Height in cm	156.7 (134.0-170.0)	162.0 (140.0-182.0)	< 0.001
Weight in kg	53.5 (32.3-81.4)	60.0 (37.6-99.3)	< 0.001
BMI in kg/m2	22.2 (15.5-29.5)	23.1 (16.5-35.0)	0.009
Cirrhosis	41 (49%)	50 (28%)	< 0.001
CKD, eGFR < 60 mL/min/1.73 m2	28 (34%)	25 (14%)	< 0.001
History of HCC treatment	18 (22%)	15 (8%)	0.002
History of IFN-based therapy	21 (25%)	42 (23%)	0.693
HCV-RNA as logIU/mL	6.1 (2.3-7.3)	5.9 (1.4-7.4)	0.894
WBC in mm3	4540 (1810-13260)	5200 (2200-11400)	0.004
Hb in g/dL	12.9 (10.2-20.1)	14.1 (10.6-17.6)	< 0.001
Platelets as × 104/mm3	14.2 (4.9-32.8)	17.4 (4.6-38.9)	< 0.001
AST in IU/L	40 (14-183)	42 (12-252)	0.589
ALT in IU/L	30 (6-139)	44 (6-394)	< 0.001
γ-GT in IU/L	25 (7-361)	37 (5-888)	0.001
AFP in ng/mL	3.9 (1-32.9)	4.8 (1.1-88.3)	0.014
eGFR	66.0 (33.0-106.9)	77.6 (30.9-156.0)	< 0.001

Values are expressed as median (range) or number (percentage). γ-GT: γ-glutamyl transferase; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; CKD: Chronic kidney disease; eGFR: Estimated glomerular filtration rate; Hb: Hemoglobin; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus; HCV-RNA: Hepatitis C virus-ribonucleic acid; IFN: Interferon; WBC: White blood cells.