Biomarkers for hepatocellular cancer

Table 2 Selected determinants of risk for hepatocellular carcinoma development

Marker	Comparison groups	SNP	Genotype	OR	P value	Ref.
DR4	HCC/HBV, HCC/HCV, HCV, controls	C626G/A638C	626C + 638AA	1.98 (1.20-3.24)	0.007	Körner et al[52]
DR4	HCC/HCV, HCV, Controls	A1322G	AG	2.34 (1.56-3.51)		Zayed et al[55]
			GG	3.51 (2.33-5.28)	0.001
TLL1	HCV-treated	rs17047200		2.37 (1.74-3.23)	2.66 × 10-8	Matsuura et al[64]
MHC class 1	HCC/HCV, Controls	Rs2596542G>A		1.39 (1.27-1.52)	4.21 × 10-13	Kumar et al[66]
(MICA)	(Japanese cohort)
MHC class II	HCC-HCV, HCV		DQB1*03:01 (HCV-Geno 1)	0.65 (0.48-0.89)	0.007	Lee et al[70]
			DQB1*06:02	3.03 (1.18-7.74)	0.02
			(HCV-non-Geno1)

HCC: Hepatocellular carcinoma; HBV: Hepatitis C virus; HCV: Hepatitis C virus; TLL1: Tolloid-like 1; MHC: Major histocompatibility complex; MICA: MHC class I polypeptide-related sequence A gene.