“Six-and-twelve” score for outcome prediction of hepatocellular carcinoma following transarterial chemoembolization. In-depth analysis from a multicenter French cohort

Table 1 Summary of points-based scores

CLIP (0 to 7 points)			MESH (0 to 6 points)		NIACE (0 to 7 points)
Portal vein thrombosis		1 point	Tumor extent: Beyond Milan criteria	1 point	Tumor nodules ≥ 3	1 point
AFP ≥ 400 ng/mL		1 point	Vascular invasion and/or Extrahepatic spread	1 point	Infiltrative HCC	1.5 points
					Nodular HCC	0 point
Child-Pugh grade	A	0 point	PS ≥ 2	1 point	AFP ≥ 200 ng/mL	1.5 points
	B	1 point	Child-Pugh grade ≥ A6	1 point
	C	2 points
Tumor extent	Unidolar and extension ≤ 50%	0 point	AFP ≥ 20 ng/mL	1 point	Child-Pugh grade A	0 point
	Multinodular and extension ≤ 50%	1 point	Alkaline phosphatase ≥ 200 IU/l	1 point	Child-Pugh grade B	1.5 points
	Massive or extension > 50%	2 points			PS ≥ 1	1.5 points

CLIP: Cancer of the Liver Italian Program; MESH: Model to Estimate Survival for Hepatocellular carcinoma; NIACE: Tumor nodularity, infiltrative nature of the tumor, alpha-fetoprotein, Child-Pugh class, and performance status.