Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling

Figure 4 Hepatic mRNA expression of genes related to sirtuin 1 signaling in obese mice treated with or without ipragliflozin and their lean littermates. A: Hepatic mRNA expression of sirtuin 1 in obese (ob/ob) mice treated with or without ipragliflozin and their lean littermates; B: Hepatic mRNA expression of peroxisome proliferator-activated receptor γ coactivator 1α in ob/ob mice treated with or without ipragliflozin and their lean littermates; C: Hepatic mRNA expression of peroxisome proliferator-activated receptor α in ob/ob mice treated with or without ipragliflozin and their lean littermates; D: Hepatic mRNA expression of fibroblast growth factor-21 in ob/ob mice treated with or without ipragliflozin and their lean littermates; E: Hepatic mRNA expression of fatty acid synthase in ob/ob mice treated with or without ipragliflozin and their lean littermates; F: Hepatic mRNA expression of acetyl-CoA carboxylase in ob/ob mice treated with or without ipragliflozin and their lean littermates. ^aP < 0.05, ^bP < 0.01 vs the ob/ob group. ACC: Acetyl-CoA carboxylase; FAS: Fatty acid synthase; FGF21: Fibroblast growth factor-21; Ipra: Ipragliflozin; NS: Not significant; PPARα: Peroxisome proliferator-activated receptor α; PGC-1α: Peroxisome proliferator-activated receptor γ coactivator 1α; ob/ob: Obese; SIRT1: Sirtuin 1. n = 8.