Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling

Figure 2 Evaluation of liver histology in obese mice treated with or without ipragliflozin and their lean littermates. A: Representative hepatic histology of mice in the lean, obese (ob/ob), ob/ob + ipragliflozin 3 mg/kg, and ob/ob + ipragliflozin 10 mg/kg groups at the end of therapy. The liver sections were stained with Oil Red O; B: Results of quantitative histomorphometric analysis of the total hepatic lipid content for each experimental group. The Oil Red O-stained areas were quantified in 8 microscopic fields at 400-fold magnification. ^bP < 0.01 vs the ob/ob group. ob/ob: Obese; Ipra: Ipragliflozin.