Drug and herbal/dietary supplements-induced liver injury: A tertiary care center experience

Figure 4 Liver injury secondary to C4 extreme. A: The liver parenchyma demonstrates a dense mononuclear inflammatory infiltrate involving the portal tracts with severe interface necroinflammatory activity (10 ×); B: In the pericentral and midzonal area of the hepatic lobules (zone 2 and 3), there is extensive hemorrhagic necrosis with extravasation of red blood cells from the central vein into the sinusoidal spaces (10 ×). Hepatocellular and canalicular cholestasis is seen (arrow) (insert 40 ×); C: The portal areas display extensive bile duct damage (arrow) (20 ×).