Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Figure 13 BPC 157 effect on gastrointestinal lesions microscopy presentation (cecum, colon). A: Cecum (HE staining, × 20), controls: Increased capillary congestion and edema of lamina propria. Extravasation of erythrocytes some of them with ischemic changes. Present at the end of 30 min portal triad obstruction (PTO) ischemia period (Ic30). With reperfusion, at 15 min of reperfusion mild capillary congestion with just focal loss of surface epithelium. Mild infiltrate of lymphocytes (Rc15). At the 24 h of reperfusion appear enhanced capillary congestion, focal erythrocytes showing ischemic changes (Rc24 h). BPC 157: Mild capillary congestion in lamina propria is seen with mild edema of lamina propria at the end of 30 min PTO ischemia period (IB30). Mild capillary congestion in lamina propria is seen at 15 min of reperfusion (RB15). At the 24 h of mild capillary congestion in lamina propria is seen. Edema of lamina propria (RB24 h); B: Colon (HE staining, × 20), controls: Increased capillary congestion and edema of lamina propria, extravasation of erythrocytes some of them with ischemic changes, focal loss of surface epithelium present at the end of 30 min PTO ischemia period (Ic30). With reperfusion, at 15 min of reperfusion mild capillary congestion with just focal loss of surface epithelium (Rc15). At the 24 h of reperfusion appear enhanced capillary congestion, focal erythrocytes showing ischemic changes (Rc24 h). BPC 157: Mild capillary congestion in lamina propria with mild edema of lamina propria at the end of 30 min PTO ischemia period (IB30). Mild capillary congestion in lamina propria is seen at 15 min of reperfusion (RB15). At the 24 h of mild capillary congestion in lamina propria is seen. Edema of lamina propria (RB24 h).