Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Figure 11 BPC 157 and yellow (orange) contrasts assessment. Application in portal vein below obstruction. A: The portal vein-superior mesenteric vein-inferior superior mesenteric vein-rectal veins-left iliac vein-inferior caval vein shunt presentation in rats with a portal triad obstruction (PTO)-ligation, with rectal inferior mesenteric vein with the tortuous presentation controls (a1: scored 3/4/4 Min/Med/Max)) or rectal inferior mesenteric vein with increased branching , BPC 157 [a2: scored 1/1/2 (µg), 1/1/2 (ng) Min/Med/Max, ^aP < 0.05, at least vs control)]; B: Application in portal vein up to obstruction before its entry into the liver. Presentation of yellow contrast filling of the liver in rats with a PTO-ligation, controls [no yellow contrast in the liver (upper, b1, b3) (scored 1/1/1 Min/Med/Max)] [note, as administration of contrast continued (b3), the portal vein ruptured], BPC 157 (immediate presentation of yellow contrast (down, b2, b4) in the liver that further progressed (down, b4) scored 4/4/4 (µg), 4/4/4 (ng) Min/Med/Max, ^aP < 0.05, at least vs control); C: Application in inferior caval vein in rats with a PTO-ligation. Presentation of the hepatic veins into the liver, and the liver presentation in rats with a PTO-ligation, controls (c1: immediate scant yellow contrast presentation in liver that would later disappear and poor presentation in hepatic veins, scored 1/1/2 Min/Med/Max)), BPC 157 (c2: immediate very abundant presentation of yellow contrast in the liver, the yellow contrast in hepatic veins abundantly seen, scored 4/4/4 (µg), 4/4/4 (ng) Min/Med/Max, ^aP < 0.05, at least vs control); D: Reperfusion with yellow ink contrast application in inferior caval vein at the level of bifurcation. Presentation at the time when liver is fully presented in BPC 157 rats [d2: scored 3/4/4 (µg), 3/4/4 (ng) Min/Med/Max, ^aP < 0.05, at least vs control)], and still not fully presented in controls (d1: scored 1/2/3 Min/Med/Max). A total injection volume of 1 mL (0.1 mL/s) in portal vein (A, B), or 2 mL (0.3 mL/s) in inferior caval vein (C, D).