Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Figure 10 BPC 157 and venography assessment. Portal vein venography below obstruction. A, B: The portal vein-superior mesenteric vein-inferior superior mesenteric vein-rectal veins-left iliac vein-inferior caval vein shunt presentation in rats with a portal triad obstruction (PTO)-ligation, controls (A), BPC 157 (B); C, D: Portal vein venography up to obstruction before its entry into the liver. Presentation of filling of the hepatic venous vascular bed, hepatic vein, inferior caval vein and the right atrium of the heart in rats with a PTO-ligation, controls (C) (note, as administration of contrast continued, the portal vein ruptured), BPC 157 (D); E, F: Inferior caval vein venography at the level of bifurcation. Blood flow through the hepatic veins into the liver, and the liver presentation in rats with a PTO-ligation, controls (E), BPC 157 (F); G, H: Reperfusion with inferior caval vein venography at the level of bifurcation. Presentation at the time when liver is presented in BPC 157 rats (H), and still not presented in controls (G). Venography 15 min of ligation-time, or at 15 min of reperfusion-time a fluoroscopy unit (Shimadzu type C-Vision Plus, Tokyo, Japan), Warmed non-ionic contrast medium (Iohexol; Omnipaque 350, GE Healthcare, Chicago, United States), a total injection volume of 1 mL (0.1 mL/s) in portal vein (A-D), or 2 mL (0.3 mL/s) in inferior caval vein (E-H).