Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Figure 2 BPC 157 effect on electrocardiogram-disturbances (left) and lienal veins (right) presentation. Electrocardiogram presentation [lead I (upper), lead II (middle), lead III (low)] at 30 min of portal triad obstruction (PTO)-ligation (Ic30; IB30) or in reperfusion (Rc15, RB15, Rc24 h, RB24 h) at 15 min and 24 h reperfusion-time in controls (Ic30, Rc15, Rc24 h) or BPC 157 (IB30, RB15, RB24 h)-rats. Note, while PTO control rats are regularly presenting with sinus tachycardia, peaked P waves (Ic30, Rc15, Rc24 h), RBBB pattern of QRS complexes (Ic30), BPC 157 application markedly prevented or reversed all of these disturbances, having sinus rhythm in normal range of heart frequency. Presentation of lienal veins, congestion and tortuosity in control rats at 30 min PTO-ligation time (Ic30, scored 3/4/4 Min/Med/Max) and at 15 min reperfusion time (Rc15, scored 2/2/2). Marked attenuation occurs in BPC 157 rats at 30 min PTO-ligation time [IB30, scored 2/2/2 (µg), 2/2/2 (ng), ^aP < 0.05, at least vs control], or in rats used to have PTO, at 15 min reperfusion time [RB15, scored 1/1/1 (µg), 1/1/1 (ng), ^aP < 0.05, at least vs control] as well as at 24 h reperfusion time.