Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

Figure 1 Counteracting effect of BPC 157 on portal, caval hypertension and aortal hypotension, sinus tachycardia, peaked P waves, in (1) ischemia and (2) reperfusion. Portal, caval and aortal pressure (mmHg); P wave amplitudes (Mv) and heart frequency (beats/min) in rats (1) with portal triad obstruction (PTO), at the end of 30 min PTO-period, or (2) after PTO, at the end of 24 h period of reperfusion, mean ± SD. Medication [BPC 157 10 µg/kg, 10 ng/kg, or saline (1 ml/rat)] was given: (1) intraperitoneally at 5 min before PTO, or as a bath administration was given at 5 min or at 30 min PTO-time; and (2) a bath administration given at 1 min or at 24 h after reperfusion initiation. The same results were obtained at 5 min reperfusion time (data not specifically shown). ^aP < 0.05, at least vs control. ECG: Electrocardiogram.