High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells

Figure 4 Effect of arachidonic acid: docosahexaenoic acid ratios on ROS production. A-C: VL17-A cells were treated with different ratios of arachidonic acid: docosahexaenoic acid for 30 min (A), 1 h (B) and 2 h (C), and ROS levels were measured. ^aP < 0.05 and ^bP < 0.01 compared to control; ^dP < 0.01 compared to 1:1; ^eP < 0.05 and ^fP < 0.01 compared to 4:1 ratio. Data is presented as mean ± SE (n = 3). AA: Arachidonic acid; DHA: Docosahexaenoic acid.