High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells

Figure 1 Effect of arachidonic acid: docosahexaenoic acid ratios on mitochondrial activity. A-C: VL17-A cells were treated with different ratios of arachidonic acid: docosahexaenoic acid and mitochondrial activity was assessed after 24 h (A), 48 h (B) and 72 h (C). ^aP < 0.05 and ^bP < 0.01 compared to control; ^cP < 0.05 and ^dP < 0.01 compared to 1:1 ratio; ^eP < 0.05 and ^fP < 0.01 compared to 4:1 ratio. Data is presented as mean ± SE (n = 3). AA: Arachidonic acid; DHA: Docosahexaenoic acid.