Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature

Table 2 Reports of patients with intrahepatic sickle cell cholestasis who underwent liver transplantation

Ref.	Year	Number of cases	Age of the patient	Outcomes
Emre et al[15]	2000	1	6	First transplant was complicated by graft failure from veno-occlusive disease, required re-LT.
				Second transplant was complicated by graft failure from hepatic artery thrombosis, required re-LT.
				The patient died 6 mo after third LT from sepsis.
Ross et al[18]	2002	1	49	The patient died 22 mo after LT due to pulmonary embolism.
Gilli et al[19]	2002	1	22	The patient was alive 3 mo after LT.
Baichi et al[7]	2005	1	27	Post-LT course was complicated by sepsis, multiorgan failure, perihepatic hematoma and hemorrhagic ascites; the patient died 35 d after LT.
Mekeel et al[9]	2007	2	8,17	Patients were followed up over a mean period of 4.2 yr.
				Patient 1 was alive at end of follow-up with mild recurrent HCV.
				Patient 2 had recurrent sickle cell hepatopathy post-transplant and died of cerebral complications 6 yr following LT.
Hurtova et al[6]	2011	5	32-47	Patient 1 died of recurrent HCV-induced decompensated cirrhosis and sepsis 11 yr after LT.
				Patient 2 had recurrent HCV with moderate fibrosis; died of ischemic cholangitis and sepsis after 4 yr after LT.
				Patient 3 had recurrent HCV infection. He was alive 8 yr after LT.
				Patient 4's post-operative course was complicated by posterior leukoencephalopathy; the patient died from sepsis 16 mo after LT.
				Patient 5 developed biliary strictures requiring stenting. The patient was alive 42 mo after LT.
Blinder et al[20]	2013	1	37	Immediate post-LT course was complicated with seizure and respiratory failure. The patient had no post-operative SCD-related complications in the 12 mo after transplant and was maintained on hydroxyurea without need for exchange transfusion.
Lui et al[3]	2018	1	29	The patient was alive 7 mo after LT with no reported complications.

LT: Liver transplant; HCV: Hepatitis C virus; SCD: Sickle cell disease.