Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma

Figure 2 Expression profile of lnc-ribonucleic acid X-inactive specific transcript and MALAT-1 in hepatocellular carcinoma tissues. Endogenous X-inactive specific transcript and MALAT-1 lnc-ribonucleic acids expression profile was analyzed in hepatocellular carcinoma (HCC) patients and healthy controls using quantified real-time polymerase chain reaction and normalized to B2M as an endogenous control. A: X-inactive specific transcript lnc-ribonucleic acid showed a significant upregulation in HCC biopsies (P = 0.048); and B: MALAT-1 was significantly down regulated in HCC biopsies (P = 0.043); however, it showed elevated expression in cirrhotic biopsies (P = 0.0136). ^aP < 0.05. HCC: Hepatocellular carcinoma.