Cyclin-dependent kinase inhibitors p21 and p27 function as critical regulators of liver regeneration following 90% hepatectomy in the rat

Figure 5 Increased expression of p21 and p27 in regenerating rat liver. The expression of p21 and p27 was investigated using western blot performed on snap-frozen liver samples collected at the indicated time points post-extended hepatectomy (eHx). Six rats were studied for each time point. A representative image is presented in the upper part of the figure, and the mean values for 6 rats per condition are shown as bar graphs. Sham animals correspond to the laparotomy group. Sham: Laparotomy control group.