Cyclin-dependent kinase inhibitors p21 and p27 function as critical regulators of liver regeneration following 90% hepatectomy in the rat

Figure 4 Expression and activation of cell cycle proteins during liver regeneration. Extracts from rat liver tissues harvested at the indicated time points after extended hepatectomy (eHx) were subjected to western blot and immunohistochemistry. A and B: Signal transducer and activator of transcription 3 (STAT3) activation; C: Retinoblastoma protein (Rb) inactivation; D: Cyclin E1, A2, and B1 expression. Bar graphs represent the mean densitometry value ± standard error of the mean n = 6 rats per time point. Sham: Laparotomy control group.