Effect of non-alcoholic beer, diet and exercise on endothelial function, nutrition and quality of life in patients with cirrhosis

Table 2 Changes in clinical and biochemical parameters

	Control (n = 21)			Intervention (n = 22)
	Baseline	Final	P value	Baseline	Final	P value
Number of daily steps	8718 ± 2998	11391 ± 4298	0.000	8533 ± 4072	11142 ± 4055	0.000
PHES score	-1 ± 2.2	0 ± 2.2	0.130	-1 ± 2.1	0 ± 2.3	0.179
CFF (Hz)	43.9 ± 7.1	45.5 ± 5.8	0.238	44.5 ± 8.1	47.2 ± 6.4	0.174
TB (mg/dL)	1.15 (0.75-1.44)	1.12 (0.85-1.28)	0.985	1.28 (0.85-2.11)	1.13 (0.8-1.865)	0.068
ALT (U/L)	43 (30-86.5)	41 (23.5-71)	0.024	43.1 (20.75-77)	36 (20.25-67.5)	0.198
AST (U/L)	47 (40-80)	45 (29.5-53.5)	0.015	50.5 (32-98)	44 (28-75.75)	0.035
Alkaline phosphatase (U/L)	123.7 ± 44.1	105 (79.50-139)	0.408	159.8 ± 64.4	159.9 ± 79.3	0.988
Albumin (g/dL)	4.1 (3.8-4.3)	4 (3.75-4.2)	0.668	3.9 (3.3-4.1)	3.9 (3.475-4.3)	0.501
Leukocytes (K/µL)	4.0 (3.7-5.15)	3.9 (3-5)	0.984	4.75 (3.725-5.925)	4.9 (3.62-6.1)	0.515
Platelets (K/µL)	77 (61.5-125)	75 (59-106.5)	0.278	93.5 (63.5-125)	107 (78.5-150.25)	0.046
Hemoglobin (g/dL)	14.2 ± 3.3	14.17 ± 1.52	0.968	14.0 ± 2.4	14.25 ± 2	0.834
INR	1.1 (1.1-1.2)	1.1 (1.1-1.2)	0.414	1.1 (1.1-1.2)	1.1 (1.0-1.2)	0.166
Glucose (mg/dL)	94 (83.5-109)	88 (82-108)	0.145	91 (81-100.5)	87.5 (84.75-96.25)	0.615
Creatinine (mg/dL)	0.72 (0.60-0.81)	0.71 (0.6-0.84)	0.403	0.71 (0.64-0.79)	0.70 (0.62-0.79)	0.723
Na (mmol/L)	140 (137.5-141)	140 (139-141.5)	0.118	138 (137-140.2)	140 (138.5-141)	0.061
K (mmol/L)	4.0 ± 0.37	4.16 ± 0.38	0.195	4.1 ± 0.25	4.2 ± 0.37	0.078
CO2 (mmol/L)	23.0 (21.5-26)	24.0 (22-26)	0.850	24.5 (21-27.25)	24 (22.95-26.15)	0.304

Data reported as mean ± standard deviation, or median (p25-p75), according to the distribution of the data. PHES: Psychometric hepatic encephalopathy score; CFF: Critical flicker frequency; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; INR: International normalized ratio.