Molecular heterogeneity in intrahepatic cholangiocarcinoma

doi:10.4254/wjh.v12.i12.1148

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 27, 2020; 12(12): 1148-1157
Published online Dec 27, 2020. doi: 10.4254/wjh.v12.i12.1148

Table 1 Frequency of genetic alteration in intrahepatic cholangiocarcinoma

Pathway	Gene	Frequency of alteration
NADPH metabolism	IDH1/2	4-36
Chromatic remodeling	BAP1	9%-25%
	ARID1A	11-36
	PBRM1	11-17
Cell cycle regulation and DNA damage response	CDKN2A	7
	CDK6	7
	TP53	3-38
	BRCA1/2	4
PI3K signaling	PIK3CA	4-6
	PTEN	1-11
Ras/Raf/MEK/ERK	EGFR	2.2
	KRAS	9-24
	NRAS	3.6
	BRAF	3-22
FGF	FGFR2	4-38

DNA: Deoxyribonucleic acid; ERK: Extracellular signal-regulated kinase; MEK: Mitogen-activated protein kinase kinase; NADPH: Nicotinamide adenosine dinucleotide phosphate; PI3K: Phosphoinositide-3-kinase.

Citation: Ahn KS, Kang KJ. Molecular heterogeneity in intrahepatic cholangiocarcinoma. World J Hepatol 2020; 12(12): 1148-1157
URL: https://www.wjgnet.com/1948-5182/full/v12/i12/1148.htm
DOI: https://dx.doi.org/10.4254/wjh.v12.i12.1148