Cannabis use history is associated with increased prevalence of ascites among patients with nonalcoholic fatty liver disease: A nationwide analysis

Table 2 Independent predictors of ascites among patients with nonalcoholic fatty liver disease, stratified by cannabis use history

Cannabis users (n = 3820)					Non-cannabis users (n = 7625)
Ascites	OR (95%CI)	P value	aOR (95%CI)	P value	Ascites	OR (95%CI)	P value	aOR (95%CI)	P value
	Univariate logistic regression		Multivariate logistic regression1			Univariate logistic regression		Multivariate logistic regression1
Diabetes	1.17 (0.84-1.62)	NS			Diabetes	1.16 (0.91-1.49)	0.23
Obesity	1.00 (0.71-1.40)	NS			Obesity	0.41 (0.31-0.53)	< 0.01	0.61 (0.46-0.81)	< 0.01
Hyperlipidemia	1.32 (0.94-1.85)	0.11	1.53 (1.08-2.17)	0.02	Hyperlipidemia	0.57 (0.43-0.77)	< 0.01	0.59 (0.44-0.80)	< 0.01
Age (continuous)	0.99 (0.98-1.01)	0.22			Age (continuous)	1.02 (0.01-1.03)	< 0.01	1.02 (1.01-1.03)	< 0.01
Race/ethnicity (categoric)					Race/ethnicity (categoric)
White	Reference				White	Reference
Black	1.13 (0.78-1.64)	NS			Black	0.80 (0.58-1.10)	0.16
Hispanic	0.87 (0.53-1.42)	NS			Hispanic	1.00 (0.70-1.42)	NS
Asian or pacific islander	1				Asian or pacific islander	1
Native American	2				Native American	1.96 (0.78-4.92)	0.15	2.60 (1.03-6.61)	0.04
Others	2.46 (1.24-4.87)	0.01	2.57 (1.24-5.31)	0.01	Others	0.71 (0.29-1.74)	NS
Comorbidity (continuous)	1.08 (1.07-1.10)	< 0.01	1.08 (1.07-1.10)	< 0.01	Comorbidity (continuous)	1.06 (1.05-1.07)	< 0.01	1.05 (1.04-1.06)	< 0.01
Sex (female)	0.80 (0.58-1.09)	0.15			Sex (female)	0.99 (0.77-1.27)	NS

¹Univariate analysis with screening P < 0.02 was used to determine variables to include in the final multivariate analysis. Hyperlipidemia, Race/ethnicity, comorbidity index, and sex included in the regression.

²Univariate analysis with screening P < 0.02 was used again, and obesity, hyperlipidemia, age, race/ethnicity, and comorbidity index were included in the multivariate regression. NS: Not statistically significant.