Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid

doi:10.4254/wjh.v12.i11.949

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Nov 27, 2020 (publication date) through Nov 30, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2020; 12(11): 949-964
Published online Nov 27, 2020. doi: 10.4254/wjh.v12.i11.949

Table 2 Effect of Terminalia bellirica fruit extracts and ellagic acid on serum hepatic function markers in aceclofenac treated rats

Groups	Total protein (g/dL)	ALP (IU/L)	SGOT (IU/L)	SGPT (IU/L)	Uric acid (mg/dL)	Creatinine (mg/dL)	LDH (IU/L)	GGT (IU/L)
Group I	6.05 ± 0.45	87.16 ± 14.19	69.37 ± 10.24	58.19 ± 09.13	1.71 ± 0.37	0.80 ± 0.33	304.76 ± 10.23	4.27 ±1.08
Group II	3.64 ± 0.14^a	157.32 ± 26.16^a1	165.40 ± 12.51^a1	158.43 ± 8.24^a1	6.87 ± 0.22^a	3.12 ± 1.31^a	689.34 ± 11.21^a1	9.29 ± 2.15^a1
Group III	5.72 ± 0.17^b1	93.49 ± 9.08^b1	85.21 ± 16.34^b1	69.09 ± 4.71^b1	2.32 ± 0.13^b1	1.37 ± 0.18^b1	401.19 ± 3.89^b1	5.87 ± 0.24^b
Group IV	5.52 ± 0.31^b1	96.65 ± 11.25^b1	89.56 ± 9.13^b1	74.98 ± 11.38^b1	2.34 ± 0.24^b1	1.49 ± 0.17^b1	449.54 ± 15.09^b1	6.18 ± 0.51^b1
Group V	4.75 ± 0.38^b2	121.49 ± 16.13^b2	140.17 ± 4.75^b1	132.11 ± 14.17^b1	3.38 ± 0.52^b2	2.72 ± 0.18^b2	587.37 ± 7.94^b2	7.69 ± 0.27^b2
Group VI	5.60 ± 0.11^b2	107.17 ± 12.37^b1	113.6 ± 4.89^b1	109.25 ± 04.85^b1	2.53 ± 0.19^b2	2.16 ± 0.06^b1	505.18 ± 11.45^b1	6.68 ± 0.39^b2

Group-I: Control rats; Group-II: Aceclofenac (ACF) treated rats; Group-III: ACF + Silymarin treated rats; Group-IV: ACF + Ellagic acid treated rats; Group-V: ACF + Aqueous extract treated rats; Group-VI: ACF + Ethyl acetate extract treated rats. Each value is expressed as mean ± SD (n = 5). Silymarin was used as a positive control. ALP: Alkaline phosphatase; LDH: Lactate dehydrogenase; GGT: Glutamyl transferase.

^aRepresents a significant difference compared with the control.

^a1P < 0.0001.

^bRepresents a significant difference compared with group II.

^b1P < 0.0005.

^b2P < 0.005.

Citation: Gupta A, Pandey A. Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid. World J Hepatol 2020; 12(11): 949-964
URL: https://www.wjgnet.com/1948-5182/full/v12/i11/949.htm
DOI: https://dx.doi.org/10.4254/wjh.v12.i11.949