Noninvasive scores for the prediction of esophageal varices and risk stratification in patients with cirrhosis

Table 2 Test characteristics for noninvasive detection of high risk esophageal varices

Non-invasive test	Sensitivity	Specificity	PPV	NPV	LR (+)	LR (-)	AUROC	HREV missed	EGDs saved
PC/SD	85%	66%			3.03	0.30	0.83	7%
TE	78%-82%	76%-77%					0.78-0.83
PLT/log10LS	100% (< 122000); 86% (< 92000)			100% (< 122k); 94% (< 92k)				0	20.6%; 6.3%
Baveno VI	87%-97%	32%-41%	6%	98%-100%	1.31	0.39	0.746-0.96	< 2%	20%-27%
Expanded Baveno VI	90%	51%		92%-96%				6.8%	51%
SSM	81%-98%	52%-66%		99.4%	2.5	0.2	0.807	2%	35.8%
EVendo	100%	49.3%		100%			0.75	2.8%	30.5%
Capsule endoscopy	72%-73.7%	90.5%-91%					0.92

Other noninvasive scores exist and may be used, as shown in Table 2; EVendo score selected based on it having the highest sensitivity, negative predictive value, and endoscopies saved, though it has not yet been validated outside of the United States. HREV: High risk esophageal varices; PPV: Positive Predictive Value; NPV: Net present value; AUROC: Area under the receiver operating characteristic; EGD: Endoscopy; PC/SD: Platelet count to spleen diameter ratio; TE: Transient elastography; PLT: Platelets; LS: Liver stiffness; SSM: Spleen stiffness measurement.