Non-invasive splenic parameters of portal hypertension: Assessment and utility

Table 2 Univariate analysis showing association of clinical parameters with clinically significant portal hypertension

Variable	Odds ratio	Cut-off	P value	Estimated AUROC curve	P value of AUROC
BMI	0.969	> 26.42	0.425	0.506	0.951
ALT (IU/L)	0.993	> 94.00	0.147	0.514	0.869
AST (IU/L)	1.002	> 64.00	0.728	0.652	0.065
GGT (IU/L)	1.001	> 85.00	0.639	0.643	0.094
ALP (IU/L)	1.001	> 96.00	0.050	0.678	0.033
Bilirubin	1.037	> 11.00	0.013a	0.722	0.007b
Platelet count (× 109)	0.979	< 126.00	< 0.001c	0.846	< 0.001
Albumin (g/L)	0.786	< 33.00	< 0.001c	0.820	< 0.001c
Prothrombin time (sec)	2.721	> 12.20	< 0.001c	0.800	< 0.001c
APRI score	2.030	> 0.81	0.008b	0.827	< 0.001c
ElastPQ median liver stiffness (kPa)	1.048	> 10.16	0.021a	0.657	0.061
ElastPQ median spleen stiffness (kPa)	1.007	> 29.99	0.368	0.712	0.010b
ElastPQ spleen area (cm2)	1.075	> 57.90	< 0.001c	0.828	0.002c
ElastPQ spleen diameter (cm)	1.651	> 13.90	0.002c	0.804	0.007b

^aP < 0.05.

^bP < 0.01.

^cP < 0.005. AUROC: Area under the receiver operating characteristic; BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyl transpeptidase; ALP: Alkaline phosphatase; APRI: AST-to-platelet-ratio-index; ElastPQ: Elastography point quantification.