Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function

Table 2 Correlation analyses of hsa-miR-21-5p and clinical or laboratory parameters

Parameter	2-ΔCt miR-21 / cel-miR-39
	Spearman r	Confidence interval	P value
Age in yr	-0.1147	-0.3188 to 0.09956	0.2789
Creatinine (µmol/L)	-0.2215	-0.4139 to -0.01013	0.0348
Bilirubin (µmol/L)	0.1484	-0.06547 to 0.3493	0.1603
ALAT (µmol/Ls)	0.1709	-0.0425 to 0.3694	0.1053
ASAT (µmol/Ls)	0.2854	0.07828 to 0.4689	0.0061
Albumin (g/L)	-0.01562	-0.2267 to 0.1969	0.8832
AFP (ng/mL)	0.1025	-0.1118 to 0.3077	0.3337
Hemoglobin (mmol/L)	0.1377	-0.07638 to 0.3396	0.1931
INR1	0.2065	-0.005615 to 0.4008	0.0496
Platelets (Gpt/L)	0.09185	-0.1224 to 0.2979	0.3865
2-ΔCt miR-122 / cel-miR-39	0.2624	0.05357 to 0.4493	0.0120

¹For 30 patients, we obtained no exact laboratory value of the International Normalized Ratio (only < 1.5). For these patients, we calculated the International Normalized Ratio based on the Quick. ALAT: Alanine aminotransferase; ASAT: Aspartate aminotransferase; AFP: Alpha-fetoprotein; INR: International Normalized Ratio; miR-21: Hsa-miR-21-5p.