PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease

Table 2 Clinical and demographic characteristics of the nonalcoholic steatohepatitis and simple steatosis population

Variables	NASH, n = 54	Simple steatosis, n = 94	P value
Female	44 (81.5%)	67 (71.3%)	0.169
Age (yr)	59 (45.8-63)	57 (47.8-64)	0.935
BMI (kg/m2)	32.7 ± 4.8	32.8 ± 4.8	0.968
WC	106.6 (100-114)	105.3 (96-113.8)	0.306
Arterial hypertension	39 (72.2%)	59 (62.8%)	0.886
Diabetes mellitus	35 (64.8%)	34 (36.2%)	0.007
Dyslipidemia	45 (83.3%)	63 (67.0%)	0.248
Fasting insulin	16.5 (11.9-31)	14 (8-18)	0.055
Fasting glucose (mg/dL)	112.5 (91-151.5)	98 (90-112)	0.019
AST (U/L)	53.5 (31.7-69)	30 (23-38)	< 0.001
ALT (U/L)	61 (36-79.3)	33 (24-49)	< 0.001
GGT (U/L)	87 (51.7-164.3)	39 (27-73.3)	< 0.001
ALP (U/L)	99 (78-127.5)	88 (72-116)	0.075
Total bilirubin (mg/dL)	0.59 (0.5-0.9)	0.6 (0.5-0.9)	0.986
Triglycerides (mg/dL)	162 (113-227.8)	163 (109.25-201)	0.544
Total cholesterol (mg/dL)	196.4 ± 39.9	195.4 ± 42.7	0.793
VLDL (mg/dL)	32 (22.8-45.3)	32 (22-40.8)	0.440
HDL (mg/dL)	46 (37.8-53)	48 (40-55)	0.432
LDL (mg/dL)	108.5 (89-138.4)	107 (88.5-137.4)	0.793
Platelets (109/L)	184 ± 67.4	308 ± 1.4	0.053
Ferritin (ng/mL)	109 (56.75-267.5)	69 (37.2-143.8)	0.019
D vitamin (ng/mL)	21.1 (17.55-25.9)	23.4 (19-28)	0.086
HOMA-IR	5.26 (2.97-8.8)	3.36 (1.77-4.7)	0.330

The data are expressed as n (%), or as mean ± SD for normally distributed variables and as median (interquartile range) when distribution of the variable was skewed. NASH: Nonalcoholic steatohepatitis; BMI: Body mass index; AST: Serum aspartate aminotransferase; VLDL: Very low-density lipoprotein; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; LDL: Low-density lipoprotein cholesterol.