Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice

Figure 6 Inflammatory signaling in the colon tissue of mice subjected to prolonged high-fat diet-feeding. Representative histology images of colonic tissue (200 X) from Young-low-fat diet (LFD), Old-LFD, and Old-HFD mice. A: Gene expression of Monocyte chemoattractant protein-1 (MCP-1); B: Interleukin 10 (IL-10); C: Interleukin 6 (IL-6); D: Interleukin 17 (IL-17); E: Forkhead box P3 (FoxP3). Data are expressed as mean ± SE. n = 10 mice per group. ^a Significantly different from Young-LFD (P < 0.05). ^b Significantly different from Old-LFD (P < 0.05). HFD: High-fat diet-feeding; LFD: Low-fat diet.