Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice

Figure 4 Inflammatory signaling in the liver tissue of mice subjected to prolonged high-fat diet-feeding. A: Gene expression of monocyte chemoattractant protein-1; B: Gene expression of interleukin; C: Gene expression of tumor necrosis factor alpha; D: Protein concentration of epidermal-gowth factor like-like module-containing mucin-like hormone receptor-like 1 also known as F4/80; E: Phosphorylated and total nuclear factor kappa-light-chain-enhancer of activated B cells. Data are expressed as mean ± SEM. n = 8-10 mice per group. ^a Significantly different from Young-LFD (P < 0.05). ^b Significantly different from Old-LFD (P < 0.05). MCP-1: Monocyte chemoattractant protein-1; IL-6: Interleukin 6; TNFα: Tumor necrosis factor alpha; NFκB: Nuclear factor kappa-light-chain-enhancer of activated B cells; LFD: Low-fat diet.