Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice

Figure 2 Metabolic characterization of mice subjected to prolonged high-fat diet-feeding. A: Five hours fasting blood glucose; B: Five hours fasting plasma insulin; C: Homeostasis model of assessment-insulin resistance index. Data are expressed as mean ± SE. n = 10 mice per group. ^aSignificantly different from Young-LFD (P < 0.05). ^bSignificantly different from Old-LFD (P < 0.05). HOMA-IR: Homeostasis model of assessment-insulin resistance; LFD: Low-fat diet.