Effectiveness of venous thromboembolism prophylaxis in patients with liver disease

Table 6 Absolute standardized differences in baseline characteristics before and after propensity score matching

	Unmatched			Matched
	No prophylaxis	Prophylaxis	ASD	No prophylaxis	Prophylaxis	ASD
	(n = 2166)	(n = 948)		(n = 903)	(n = 903)
Age (yr)	58.1 ± 11.6	60.3 ± 11.8	0.153	60.1 ± 11.9	60.2 ± 11.8	0.00844
Male	1349 (62.3)	561(59.2)	0.0639	572 (63.3)	535 (59.2)	0.0842
RRT	819 (37.8)	270 (28.5)	0.199	221 (24.5)	267 (29.6)	0.115
CKD	577 (26.6)	247 (26.1)	0.0133	226 (25.0)	238 (26.4)	0.0304
Lung disease	397 (18.3)	236 (24.9)	0.160	218 (24.1)	218 (24.1)	0.000
Heart failure	360 (16.6)	210 (22.2)	0.140	192 (21.3)	196 (21.7)	0.0108
MVP	755 (34.9)	300 (31.6)	0.0682	291 (32.2)	286 (31.7)	0.0119
VTE risk score			0.390			0.218
Unknown	447 (20.6)	80 (8.4)		103 (11.4)	78 (8.6)
Low	86 (4.0)	17 (1.8)		26 (2.9)	17 (1.9)
Medium	1341 (61.9)	716 (75.5)		591 (65.4)	680 (75.3)
High	292 (13.5)	135 (14.2)		183 (20.3)	128 (14.2)
BMI (kg/m2)	24.2 ± 0.19	24.4 ± 0.20	0.0180	24.4 ± 0.20	24.4 ± 0.20	0.00
INR	1.51 ± 0.67	1.27 ± 0.31	0.478	1.4 ± 0.57	1.3 ± 0.32	0.216
Platelet count (k/µL)	108.3 ± 76.2	159.8 ± 108.0	0.551	144.2 ± 92.5	151.0 ± 97.0	0.0718
aPTT (s)	37.68 ± 13.6	34.3 ± 10.1	0.282	34.8 ± 12.0	34.4 ± 10.2	0.0359
Albumin (g/dL)	2.8 ± 0.70	2.9 ± 0.68	0.118	2.9 ± 0.70	2.9 ± 0.67	0.00
Tbili (mg/dL)	5.88 ± 8.57	3.68 ± 6.49	0.288	4.0 ± 7.1	3.8 ± 6.6	0.0292
SCr (mg/dL)	1.65 ± 1.41	1.59 ± 1.50	0.0414	1.5 ± 1.3	1.6 ± 1.5	0.0713
Hemoglobin (g/dL)	10.0 ± 2.3	10.7 ± 2.1	0.269	10.4 ± 2.3	10.7 ± 2.1	0.136
Liver disease etiology			0.0964			0.0416
Alcoholic	745 (34.4)	296 (31.2)		278 (30.8)	286 (31.7)
NASH	75 (3.5)	25 (2.6)		27 (3.0)	22 (2.4)
Other1	1239 (57.2)	585 (61.7)		563 (62.3)	557 (61.7)
Acute hepatitis	107 (4.9)	42 (4.4)		35 (3.9)	38 (4.2)
MELD score	21.1 ± 10.3	17.2 ± 8.3	0.422	17.0 ± 9.1	17.4 ± 8.3	0.0459
MELD category			0.431			0.210
>40	102 (4.7)	8 (0.8)		20 (2.2)	8 (0.89)
30-39	364 (16.8)	74 (7.8)		71 (7.9)	74 (8.2)
20-29	637 (29.4)	238 (25.1)		205 (22.7)	233 (25.8)
10-19	692 (31.9)	402 (42.4)		338 (37.4)	386 (42.7)
< 10	371 (17.1)	226 (23.8)		269 (29.8)	202 (22.4)

Data presented as n (%) or mean ± SD.

¹Other liver disease includes primary sclerosing cholangitis, biliary cirrhosis, cirrhosis due to alpha-1 antitrypsin deficiency, and any other liver disease not included above. RRT: Renal replacement therapy; CKD: Chronic kidney disease; MVP: Mechanical venous thromboembolism prophylaxis; BMI: Body mass index; INR: International normalized ratio; aPTT: Activated partial thromboplastin time; Tbili: Total bilirubin; SCr: Serum creatinine; NASH: Non-alcoholic steatohepatitis; MELD: Model for end-stage liver disease; ASD: Absolute standardized difference.