Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study

Figure 1 Angiogenic phenotype of hepatocellular carcinoma cells. A: Vascular endothelial growth factor (VEGF) A shows a low intensity (score 2+) in aggressive cases with vascular invasion; B: VEGF-A is well expressed (score 3+) in well differentiated carcinomas; C: Cyclooxygenase-2 (COX-2) presents low intensity (score 1+) in well-differentiated carcinomas; D: COX-2 becomes upregulated (score 3+) in dedifferentiated tumors.