Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c

Table 2 Baseline characteristics of patients with hepatitis C virus and type 2 diabetes mellitus

	All patients (n = 106)	SVR12 not achieved (n = 8)	SVR12 achieved (n = 98)	P-value
Age (mean ± SD, yr)	63.2 ± 0.5	59.6 ± 1.4	63.5 ± 0.5	0.04
Sex
Male	99.1 (105)	7.60 (8)	92.40 (97)	0.74
Female	0.90 (1)	0.00 (0)	100.0 (1)
Race/ethnicity
White	27.40 (29)	6.90 (2)	93.20 (27)	0.15
African American	36.80 (39)	5.10 (2)	94.90 (37)
Hispanic	25.50 (27)	11.1 (3)	88.90 (24)
Asian	1.90 (2)	50.0 (1)	50.00 (1)
Other	8.50 (9)	0.00 (0)	100.0 (9)
Cirrhosis
Yes	53.80 (57)	8.80 (5)	91.20 (52)	0.61
No	46.20 (49)	6.10 (3)	93.90 (46)
CTP class
CTP A	82.50 (47)	6.40 (3)	93.60 (44)	0.21
CTP B	14.00 (8)	25.0 (2)	75.0 (6)
CTP C	3.50 (2)	0.00 (0)	100.0 (2)
Treatment status
Naive	67.90 (72)	5.60 (4)	94.40 (68)	0.26
Experienced	32.10 (34)	11.8 (4)	88.20 (30)
HCV genotype
Genotype 1a	56.60 (60)	10.0 (6)	90.00 (54)	0.67
Genotype 1b	22.60 (24)	4.20 (1)	95.80 (23)
Genotype 2	12.30 (13)	0.00 (0)	100.0 (13)
Genotype 3	7.60 (8)	12.5 (1)	87.50 (7)
Genotype 4	0.90 (1)	0.00 (0)	100.0 (1)
Treatment regimen
Sofosbuvir/Simeprevir	39.60 (42)	7.10 (3)	92.90 (39)	0.96
Sofosbuvir/Ribavirin	17.00 (18)	5.60 (1)	94.40 (17)
PrOD	18.90 (20)	10.0 (2)	90.00 (18)
Sofosbuvir/Ledipasvir	24.50 (26)	7.70 (2)	92.30 (24)
Body mass index
Normal	15.10 (16)	6.20 (1)	93.80 (15)	0.78
Overweight	41.50 (44)	9.10 (4)	90.90 (40)
Obese	28.30 (30)	6.70 (2)	93.30 (28)
Severely obese	10.40 (12)	8.30 (1)	91.70 (11)
Very severely obese	4.70 (4)	0.00 (0)	100.0 (4)
Co-HIV infection	2.80 (3)	100.0 (3)	0.0 (0)	0.62
HTN	89.60 (95)	8.40 (8)	91.60 (87)	0.32
HLD	74.50 (79)	6.30 (5)	93.70 (74)	0.42
Metabolic syndrome	80.20 (85)	7.10 (6)	92.90 (79)	0.71

HCV: Hepatitis C virus; HIV: Human immunodeficiency virus; HTN: Hypertension; HLD: Hyperlipidemia; PrOD: Ombitasvir/Paritaprevir/Ritonavir/ Dasabuvir; SVR: Sustained virologic response; CTP: Child-Turcotte-Pugh.