Micro-RNAs in hepatitis B virus-related chronic liver diseases and hepatocellular carcinoma

Table 1 miRNAs involved in hepatitis B virus infection

miRNA	Validated target	Effect on HBV	Ref.
miRNA targeting HBV transcripts
miR-15a/miR-16-1	HBx	↓	[28,33]
miR-20a/miR-92a-1	Polymerase/HBx	↓	[29]
miR-122	Polymerase/HBc	↓	[27]
miR-125a	HBsAg	↓	[23-26,32]
miR-199a-3p	HBsAg	↓	[22]
miR-205	HBx	↓	[31]
miR-210	HBsAg pre-S1 region	↓	[22]
miR-1231	HBc	↓	[30]
miRNAs targeting HBV regulators
miR-1	HDAC4	↑	[51-53]
miR-15b	HNF1	↑	[50]
miR-34a	CCL22	↓	[60]
miR-122	Cyclin G1	↑	[43-45]
	HO-1		[45,46]
miR-130a	PGC1 PPAR	↓	[41]
miR-141	PPAR	↓	[24,40]
miR-146a	STAT1	↑	[58]
miR-152	DNMT-1	↑	[54-57]
miR-155	C/EBP	↓	[35-38]
	SOCS1	↓	[39]
miR-370	NFIA	↑	[49]
miR-372/373	NFIB	↑	[48]
miR-501	HBXIP	↑	[42]
miR-548a	IFNλ-1	↑	[59]

MiRNAs are listed according to their increasing number name. ↓: Suppress HBV infection; ↑: Promote HBV infection; HBV: Hepatitis B virus.