Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations: A case report and review of the literature

Figure 4 Vaccine escape mutations in the patient’s hepatitis B virus strain. Alignment of the HBs antigen amino acid sequence (SHBs) of the patient´s strain with a HBV genotype F consensus sequence derived from the HIV-grade database (http://www.hiv-grade.de). Amino acids are named according to the one-letter code. Dots in the patient´s sequence represent amino acids identical to those in the consensus sequence. Positions relevant for drug resistance are indicated by blue boxes. Red asterisks denote positions in the patient´s strain (i.e., 109, 128, 129, 131, and 134) where both the amino acid of the consensus strain and the vaccine escape mutation were observed. HBV: Hepatitis B virus.