Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation

Table 2 In vitro release kinetics data

Prodrug	Incubation medium
	HClbuffer,pH 1.2	Phosphatebuffer,pH 7.4	Stomach homogenates	Intestinal homogenates
				K ± SD,min-11	t1/2,min	% Prodrug hydrolysed	% INH released
NI	Stable	Stable	Negligible	3.4 × 10-3	233.42	94.93	46.10
MGI	Stable	Stable	Negligible	3.3 × 10-3	217.34	70.11	33.83
MI	Stable	Stable	Negligible	5.1 × 10-3	181.36	86.55	44.26

¹Average of three readings; follows first-order kinetics.