Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma: A critical appraisal of the evidence

Table 4 Clinical outcomes of liver resection in large or small hepatocellular carcinoma

Ref.	Recruitment period	n	Overall survival (%)			Median OS (mo)	Disease free survival (%)			Median DFS (mo)
			1-yr	3-yr	5-yr		1-yr	3-yr	5-yr
Large HCC
Poon et al[36]	1991-2000	120	60.6	37.8	27.5	18.8	32.0	14.1	9.5	5.5
Yeh et al[38]	1982-2001	211	48.1	24.0	16.7	NS	32.9	18.8	12.7	NS
Zhou et al[37]	1964-1999	621	68.0	37.3	26.2	NS	NS	NS	NS	NS
Liau et al[41]	1985-2002	82	73.0	49.0	33.0	32.0	80.0	44.0	24.0	22.0
Nagano et al[40]	1985-2001	26	41.0	29.3	29.3	10.1	65.4	49.0	NS	29.0
Pawlik et al[10]	1981-2000	300	64.9	36.7	26.9	20.3	NS	NS	NS	NS
Lee et al[43]	1997-2003	100	66.0	44.0	31.0	NS	43.0	26.0	20.0	NS
Pandey et al[44]	1995-2006	166	65.0	35.0	28.6	20.0	NS	NS	NS	NS
Shah et al[42]	1993-2004	24	69.0	63.0	54.0	NS	41.0	23.0	NS	8.4
Young et al[45]	1994-2006	42	70.0	45.0	45.0	NS	62.0	49.0	43.0	NS
Shimada et al[46]	1988-2004	85	NS	NS	31.5	NS	NS	NS	NS	NS
Taniai et al[47]	1987-2006	29	51.9	33.6	33.6	NS	48.4	21.5	21.5	NS
Choi et al[50]	1996-2006	50	70.0	50.2	40.2	NS	49.0	38.6	38.6	9.0
Miyoshi et al[49]	1987-2004	22	71.8	60.3	45.2	20.5	53.3	29.1	18.2	12.0
Ng et al[48]	1990-2008	44	66.4	38.1	27.8	21.5	49.6	23.9	19.1	10.7
Yamashita et al[51]	1995-2007	53	74.0	43.0	35.0	NS	50.0	40.0	24.0	NS
Truant et al[35]	2000-2010	52	NS	NS	43.3	NS	NS	NS	39.3	NS
Allemann et al[55]	1997-2009	22	84.0	72.0	45.0	27.0	64.0	28.0	27.0	10.0
Ariizumi et al[54] (S)	1990-2008	NS	81.0	60.0	47.0	14.3	41.0	18.0	12.0	NS
Ariizumi et al[54] (M)	1990-2008	NS	88.0	83.0	79.0	38.5	76.0	54.0	48.0	NS
Shrager et al[52]	1992-2010	130	56.9	30.2	18.8	17.0	31.8	13.4	11.5	6.7
Yang et al[53]	2002-2011	258	84.0	62.0	33.0	NS	61.0	24.0	6.0	NS
Small HCC
Miyoshi et al[49]	1987-2004	230	89.3	74.6	60.4	48.2	68.0	43.7	26.7	20.0
Allemann et al[55]	1997-2009	79	75.0	42.0	21.0	24.0	50.0	18.0	14.0	15.0
Poon et al[36]	1991-2000	368	83.3	64.2	51.6	62.8	64.6	41.8	28.2	25.4
Yeh et al[38]	1982-2001	778	81.4	57.3	39.5	NS	61.2	40.7	32.1	NS
Zhou et al[37]	1964-1999	2039	85.0	65.1	54.3	NS	NS	NS	NS	NS
Liau et al[41]	1985-2002	111	80.0	58.0	39.0	40.0	70.0	49.0	31.0	28.0
Nagano et al[40]	1985-2001	143	93.1	74.5	44.7	53.4	80.0	46.5	31.0	33.9
Shah et al[42]	1993-2004	165	88.0	70.0	53.0	NS	76.0	53.0	43.0	38.0
Young et al[45]	1994-2006	43	82.0	63.0	57.0	NS	71.0	54.0	48.0	NS
Taniai et al[47]	1987-2006	291	81.0	61.4	45.0	NS	74.6	37.1	25.4	NS
Choi et al[50]	1996-2006	447	91.3	77.2	65.9	NS	72.7	53.1	45.4	35.0
Yamashita et al[51]	1995-2007	412	89.0	67.0	54.0	NS	72.0	45.0	37.0	NS
Truant et al[35]	2000-2010	37	NS	NS	89.2	NS	NS	NS	60.7	NS
Yang et al[53]	2002-2011	293	83.0	66.0	39.0	NS	56.0	26.0	9.0	NS

HCC: Hepatocellular carcinoma; M: Multi nodules; S: Single nodule.