Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma: A critical appraisal of the evidence

Table 3 Characteristics of patients classified as large or small hepatocellular carcinoma

Ref.	Year	n	Male (%)	Cirrhosis (%)	HBV (%)	HCV (%)	Median tumor diameter (cm)
Large HCC
Poon et al[36]	2002	120	99 (82.5)	32 (26.7)	103 (85.8)	NS	13.8
Yeh et al[38]	2003	211	164 (77.7)	63 (29.9)	163 (77.3)	16 (7.6)	13.9
Zhou et al[37]	2003	621	NS	NS	NS	NS	NS
Liau et al[41]	2005	82	48 (58.5)	8 (9.8)	NS	NS	14.7
Nagano et al[40]	2005	26	19 (73.1)	5 (19.2)	14 (53.8)	3 (11.5)	14.8
Pawlik et al[10]	2005	300	222 (74.0)	NS	188 (62.7)	NS	NS
Lee et al[43]	2007	100	77 (77.0)	NS	NS	NS	12.5
Pandey et al[44]	2007	166	143 (86.1)	80 (48.2)	130 (78.3)	2 (1.2)	13.0
Shah et al[42]	2007	24	NS	NS	9 (37.5)	1 (4.2)	13.1
Young et al[45]	2007	42	29 (69.0)	2 (4.8)	NS	NS	14.0
Shimada et al[46]	2008	85	72 (84.7)	NS	27 (31.8)	19 (22.4)	12.0
Taniai et al[47]	2008	29	26 (89.7)	12 (41.4)	6 (20.7)	17 (58.6)	13.5
Choi et al[50]	2009	50	34 (68.0)	13 (26.0)	33 (66.0)	1 (2.0)	NS
Miyoshi et al[49]	2009	22	19 (86.4)	5 (22.7)	NS	NS	12.0
Ng et al[48]	2009	44	33 (75.0)	NS	15 (34.1)	3 (6.8)	12.4
Yamashita et al[51]	2011	53	48 (90.6)	NS	18 (34.0)	22 (41.5)	13.2
Truant et al[35]	2012	52	38 (73.1)	23 (44.2)	6 (11.5)	NS	14.0
Allemann et al[55]	2013	22	NS	9 (40.9)	4 (18.2)	2 (9.1)	13.5
Ariizumi et al[54]	2013	107	NS	NS	NS	NS	NS
Shrager et al[52]	2013	130	98 (75.4)	NS	56 (43.1)	23 (17.7)	14.2
Yang et al[53]	2013	258	212 (82.2)	171 (66.3)	195 (75.6)	NS	13.2
Small HCC
Miyoshi et al[49]	2009	230	160 (69.6)	114 (49.6)	NS	NS	3.4
Allemann et al[55]	2013	79	NS	61 (77.2)	10 (12.7)	13 (16.5)	4.9
Poon et al[36]	2002	368	295 (80.2)	203 (55.2)	311 (84.5)	NS	5.4
Yeh et al[38]	2003	778	776 (99.7)	591 (76.0)	616 (79.2)	305 (39.2)	4.5
Zhou et al[37]	2003	2039	NS	NS	NS	NS	NS
Liau et al[41]	2005	111	80 (72.1)	40 (36.0)	NS	NS	6.1
Nagano et al[40]	2005	143	112 (78.3)	81 (56.6)	17 (11.9)	87 (60.8)	3.3
Shah et al[42]	2007	165	NS	NS	73 (44.2)	36 (21.8)	4.7
Young et al[45]	2007	43	30 (69.8)	10 (23.3)	NS	NS	5.0
Taniai et al[47]	2008	291	225 (77.3)	156 (53.6)	135 (46.4)	78 (26.8)	3.7
Choi et al[50]	2009	447	344 (77.0)	244 (54.6)	331 (74.0)	26 (5.8)	NS
Yamashita et al[51]	2011	412	328 (79.6)	NS	60 (14.6)	311 (75.5)	3.8
Truant et al[35]	2012	37	28 (75.7)	26 (70.3)	1 (2.7)	NS	4.7
Yang et al[53]	2013	293	236 (80.5)	201 (68.6)	216 (73.7)	NS	6.7

HCC: Hepatocellular carcinoma.