Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma: A critical appraisal of the evidence

Table 2 Clinical outcomes of liver resection in BCLC stage B or C hepatocellular carcinoma

Ref.	Recruitment period	n	Overall survival (%)			Median OS (mo)	Disease free survival (%)			Median DFS (mo)
			1-yr	3-yr	5-yr		1-yr	3-yr	5-yr
BCLC stage B
Régimbeau et al[25]	1984-1996	94	69.0	45.0	31.0	NS	51.0	35.0	21.0	NS
Hanazaki et al[19]	1983-1997	133	70.0	38.0	28.0	NS	65.0	26.0	20.0	NS
Ng et al[10]	1982-2001	380	74.0	50.0	39.0	36.9	54.0	38.0	26.0	15.6
Chen et al[26] (TP1)	1990-2003	959	67.8	50.7	27.9	16.0	56.5	34.7	18.9	10.0
Chen et al[26] (TP2)	1990-2003	1143	71.2	58.8	38.7	19.0	61.5	38.6	23.8	17.0
Cho et al[26]	1998-2001	230	85.0	59.3	52.9	NS	58.3	40.0	31.7	NS
Vitale et al[31]	2000-2007	124	85.0	56.0	NS	NS	NS	NS	NS	NS
Yang et al[11]	1992-2002	260	87.0	55.5	38.2	45.5	82.4	51.0	35.0	36.7
Zhou et al[29] (SX)	2001-2003	56	69.6	32.1	21.1	NS	39.2	21.4	8.9	NS
Zhou et al[29] (TCSX)	2001-2003	52	73.1	40.4	30.7	NS	48.9	25.5	12.8	NS
Delis et al[27]	2002-2008	66	69.0	37.0	32.0	36.0	60.0	33.0	29.0	29.0
Lin et al[30]	2001-2007	93	83.0	49.0	30.0	27.6	NS	NS	NS	NS
Ramacciato et al[28]	2000-2006	51	NS	NS	56.1	68.0	NS	NS	41.3	NS
Xu et al[21]	1991-2004	165	75.6	57.4	40.2	NS	NS	NS	NS	NS
Wei et al[22]	2003-2007	51	84.3	54.9	NS	NS	70.2	45.4	NS	NS
Zhou et al[20]	1995-2002	85	93.8	56.2	47.0	56.0	74.3	34.4	14.8	36.0
Chang et al[32]	1991-2006	318	81.2	59.4	46.5	NS	55.8	39.4	31.9	6.0
Hsu et al[34]	2002-2010	268	82.0	68.0	46.0	NS	NS	NS	NS	NS
Ma et al[23]	1998-2011	178	77.0	26.0	10.0	27.9	49.0	18.0	NS	16.8
Torzilli et al[12]	1990-2009	737	88.0	71.0	57.0	NS	63.0	38.0	27.0	NS
Zhong et al[120]	2000-2007	660	91.0	67.0	44.0	NS	NS	NS	NS	NS
BCLC stage C
Ohkubo et al[79]	1985-1997	47	53.9	33.2	23.9	NS	31.2	17.9	NS	NS
Wu et al[57] (SX 1st bifurcation)	1990-1998	15	80.0	44.0	26.4	NS	67.0	32.0	21.1	NS
Wu et al[57] (SX 1st)	1990-1998	97	68.0	34.0	28.5	NS	51.0	22.0	20.4	NS
Minagawa et al[58]	1989-1998	18	82.0	42.0	42.0	40.8	NS	NS	NS	7.8
Poon et al[59]	1989-2000	20	30.0	13.3	13.3	6.0	15.0	5.0	5.0	2.9
Fan et al[60] (SX, CHT)	1997-2002	84	29.3	15.6	NS	15.1	NS	NS	NS	NS
Fan et al[60] (SX)	1997-2002	24	22.7	0.0	NS	10.1	NS	NS	NS	NS
Pawlik et al[10]	1984-1999	102	45.0	17.0	10.0	11.0	NS	NS	NS	NS
Chen et al[62] (SX 1st)	1990-2003	286	58.7	22.7	18.1	18.8	NS	NS	NS	NS
Chen et al[62] (SX Main)	1990-2003	152	39.5	5.7	0.0	10.1	NS	NS	NS	NS
Ikai et al[64]	1990-2002	78	45.7	21.7	10.9	8.9	NS	NS	NS	NS
Le Treut et al[63]	1988-2004	26	38.5	20.0	13.0	9.0	NS	NS	NS	NS
Kamiyama et al[66] (RTSX)	1990-2006	15	86.2	43.5	34.8	19.6	NS	NS	NS	NS
Kamiyama et al[66] (SX)	1990-2006	28	39.0	13.1	13.1	9.1	NS	NS	NS	NS
Takizawa et al[65]	1992-2003	12	63.6	53.0	26.0	26.0	NS	NS	NS	NS
Ban et al[69]	1992-2008	45	69.6	37.4	22.4	20.0	30.4	21.2	0.0	NS
Inoue et al[70] (TB)	1995-2006	20	58.0	46.0	39.0	NS	34.0	34.0	23.0	NS
Inoue et al[70] (EN)	1995-2006	29	65.0	41.0	41.0	NS	38.0	22.0	18.0	NS
Kondo et al[68] (SX, Main)	1996-2004	5	20.0	NS	NS	NS	NS	NS	NS	NS
Kondo et al[68] (SX, 1st-3rd)	1996-2004	43	54.0	33.0	27.0	NS	NS	NS	NS	NS
Peng et al[67] (TC)	1996-2004	51	50.9	33.8	21.6	13.0	NS	NS	NS	NS
Peng et al[67] (SX)	1996-2004	53	33.3	17.0	8.5	9.0	NS	NS	NS	NS
Vitale et al[31]	2000-2007	48	55.0	44.0	0.0	NS	NS	NS	NS	NS
Shi et al[71]	2001-2003	406	34.4	13.0	NS	NS	13.3	4.7	NS	NS
Xu et al[21]	1991-2004	95	37.5	18.2	14.2	NS	NS	NS	NS	NS
Lin et al[72] (TP1)	1996-2006	21	77.0	19.0	5.0	21.0	NS	NS	NS	NS
Lin et al[72] (TP2)	1996-2006	47	76.0	51.0	36.0	36.0	NS	NS	NS	NS
Peng et al[14]	2002-2007	201	42.0	14.1	11.1	20.0	NS	NS	NS	NS
Wei et al[22]	2003-2007	17	52.9	29.4	NS	NS	35.2	17.6	NS	NS
Chang et al[32]	1990-2009	34	45.0	20.0	20.0	NS	NS	NS	NS	NS
Huang et al[56] (SX)	1991-2006	160	57.6	33.8	29.1	NS	35.3	27.2	25.0	NS
Huang et al[56] (SXTC)	1998-2008	54	71.0	35.0	11.0	NS	NS	NS	NS	NS
Liu et al[74]	1998-2008	62	71.0	24.0	6.0	NS	NS	NS	NS	NS
Ma et al[23]	2000-2009	65	84.0	NS	NS	17	79.0	NS	NS	14.0
Li et al[75]	1998-2011	46	37.0	16.0	NS	16.9	16.0	NS	NS	7.7
Nitta et al[77]	1997-2009	13	53.8	15.4	NS	NS	NS	NS	NS	NS
Roayaie et al[78]	2006-2008	35	78.0	37.4	32.7	NS	45.0	11.8	11.8	NS
Tang et al[76]	1992-2010	164	50.0	23.0	14	13.1	40.0	20.0	18.0	8.1
Torzilli et al[12]	2006-2008	186	40.1	13.6	NS	10.0	NS	NS	NS	NS
Zhong et al[120]	1990-2009	297	76.0	49.0	38.0	NS	46.0	28.0	18.0	NS
Ohkubo et al[79]	2000-2007	248	81.0	46.0	20.0	NS	NS	NS	NS	NS

TP: Time period; SX: Surgery; TC: Trans- arterial chemoembolization; CHT: Chemotherapy; TB: Thrombectomy; EN: En.bloc, RT: Radiotherapy.