Management of restless legs syndrome in chronic liver disease: A challenge for the correct diagnosis and therapy

Table 8 Analysis of factors for association with the presence of augmentation

Factor	n	Univariate		Multivariate
		OR (95%CI)	P value	OR (95%CI)	P value
Age	170	1.07 (0.7-1.2)	0.24	1.1 (0.9-1.3)	0.20
BMI	170	1.3 (0.9-1.5)	0.45	1.6 (1.0-1.9)	0.40
IRLS	170	1.5 (1.1-2.2)	0.36	1.7 (1.2-2.2)	0.57
Alcohol abuse	139	2.3 (0.9-4.1)	< 0.001	3.75 (2.7-6.2)	< 0.001
Daily pramipexole	170	3.6 (2.1-6.8)	< 0.001	7.2 (4.1-15.2)	< 0.001
Treatment duration, > 75 d/< 75 d	170	2.3 (1.3-4.2)	0.036	6.6 (3.1-11.2)	0.01
ALT	170	1.3 (0.9-1.6)	0.21	3.1 (1.7-3.9)	0.54
AST	170	1.6 (0.8-1.7)	0.50	2.7 (0.7-4.2)	0.76
Iron-free level	170	2.9 (0.9-4.1)	0.01	5.05 (1.1-12.2)	0.06
Vit. B12	170	4.25 (1.3-9.7)	0.01	6.9 (4.7-7.6)	0.01
Folate	170	4.1 (3.1-13.6)	0.01	5.7 (4.2-8.2)	0.01
Vit. D-OH25	170	4.8 (3.4-12.9)	0.01	5.67 (2.4-8.9)	0.01

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; CI: Confidence interval; IRLS: International restless leg syndrome severity; OR: Odds ratio; Vit.: Vitamin.