Multipotent stromal cells stimulate liver regeneration by influencing the macrophage polarization in rat

Figure 3 Influence of the transplantation on macrophage polarization profiles. CD68+ cells (green) in the liver in the comparison group (A) and in the residual liver in the MSC transplantation group (B) on day 7 after the surgery. The diagram shows dynamic changes in the CD68+ cell content liver in the comparison group and in the multipotent stromal cells (MSC) transplantation group (E); Relative quantities of CD206+ cells (green) in the liver in the comparison group (C) and in the residual liver in the MSC transplantation group (D) on day 7 after the surgery; The diagram shows dynamic changes in the CD206+ cell content in the course of regeneration; cell nuclei are counterstained with 4′,6-Diamidino-2-phenylindole (blue). In E and F, white columns represent the sham-operated animals, gray columns represent the comparison group, black columns represent the MSC transplantation group, horizontal axis represents time elapsed after the surgery. SR: Subtotal resection; SO: Sham-operated animals; MSC: Multipotent stromal cells.