Retrospective Cohort Study
Copyright ©The Author(s) 2018.
World J Hepatol. Oct 27, 2018; 10(10): 731-742
Published online Oct 27, 2018. doi: 10.4254/wjh.v10.i10.731
Table 3 Univariate and multivariate analysis of factors associated with a SSM decrease > 20%
Entire Population (n = 134)
VariableUnivariate analysis
Multivariate analysis
LR Chi-2 = 16.48AIC = 171.8
AUROC = 0.6821BIC = 177.6
SSM Decrease >20% (n = 60)No SSM Decrease >20% (n = 74)OR (95%CI)P valueOR (95%CI)P value
Age (yr)62 (52-69)56 (50-68)1.005 (0.975-1.037)0.727
Sex (male)21 (28.4)21 (35)1.359 (0.653-2.828)0.412
Presence of varices (n = 67) (yes)9 (34.2)24 (82.8)0.110 (0.031-0.388)0.001
Spleen diameter (cm)13.6 (11.65-15.15)14.5 (13-16)0.800 (0.660-0.970)0.023
Child Pugh Score5 (5-6)5 (5-6)0.885 (0.601-1.303)0.535
Child Pugh Score B (yes)8 (13.3)11 (14.9)0.881 (0.330-2.352)0.801
MELD score8 (7-10)9 (8-10)0.786 (0.648-0.954)0.015
MELD > 1012 (20)30 (40.5)0.367 (0.167-0.804)0.012
AST (U/L)54.5 (38-85)56 (35.5-87)0.996 (0.987-1.004)0.322
ALT (U/L)62 (37-105)53 (40-90)1.002 (0.995-1.008)0.620
ALT ≥ 2 × ULN at BL59.5 (37.5-101)54 (40-91.5)1.326 (0.597-2.944)0.489
INR1.09 (1.05-1.17)1.12 (1.09-1.21)0.127 (0.001-0.551)0.023
Bilirubin (mg/dl)0.85 (0.65-1.16)1.02 (0.71-1.52)0.903 (0.535-1.525)0.703
Albumin (g/dl)3.8 (3.52-4.12)3.78 (3.52-4.12)2.096 (0.959-4.581)0.063
Creatinine (mg/d)0.8 (0.7-1)0.81 (0.69-0.93)0.327 (0.674-1.585)0.165
Platelet count (10^9/L)118 (92-154)91 (74-137)1.002 (0.996-1.007)0.579
LSM BL (kPa)18 (14.6-25.7)21.1 (14-38.5)0.988 (0.962-1.015)0.391
LSM SVR24 (kPa)12.4 (9.4-18)17.5 (10.4-32.4)0.944 (0.908-0.981)0.004
SSM BL (kPa)60.4 (45.7-70.7)53.2 (37.4-75)1.012 (0.992-1.032)0.225
LSPS BL2.17 (1.33-3.77)4.15 (1.65-6.26)0.817 (0.684-0.975)0.025
LSM decrease (Delta, %)33 (18.1–44.6)19.4 (0–31.3)0.0332 (0.005-0.225)< 0.00010.0332 (0.005-0.225)< 0.0001
LSM decrease > 10% (yes)54 (90)54 (73)3.333 (1.242-8.946)0.017
LSM decrease > 20% (yes)47 (78.3)41 (55.4)2.910 (1.352-6.262)0.006