Copyright
©The Author(s) 2018.
World J Hepatol. Oct 27, 2018; 10(10): 731-742
Published online Oct 27, 2018. doi: 10.4254/wjh.v10.i10.731
Published online Oct 27, 2018. doi: 10.4254/wjh.v10.i10.731
Entire Population (n = 134) | ||||||
Variable | Univariate analysis | Multivariate analysis | ||||
LR Chi-2 = 16.48 | AIC = 171.8 | |||||
AUROC = 0.6821 | BIC = 177.6 | |||||
SSM Decrease >20% (n = 60) | No SSM Decrease >20% (n = 74) | OR (95%CI) | P value | OR (95%CI) | P value | |
Age (yr) | 62 (52-69) | 56 (50-68) | 1.005 (0.975-1.037) | 0.727 | ||
Sex (male) | 21 (28.4) | 21 (35) | 1.359 (0.653-2.828) | 0.412 | ||
Presence of varices (n = 67) (yes) | 9 (34.2) | 24 (82.8) | 0.110 (0.031-0.388) | 0.001 | ||
Spleen diameter (cm) | 13.6 (11.65-15.15) | 14.5 (13-16) | 0.800 (0.660-0.970) | 0.023 | ||
Child Pugh Score | 5 (5-6) | 5 (5-6) | 0.885 (0.601-1.303) | 0.535 | ||
Child Pugh Score B (yes) | 8 (13.3) | 11 (14.9) | 0.881 (0.330-2.352) | 0.801 | ||
MELD score | 8 (7-10) | 9 (8-10) | 0.786 (0.648-0.954) | 0.015 | ||
MELD > 10 | 12 (20) | 30 (40.5) | 0.367 (0.167-0.804) | 0.012 | ||
AST (U/L) | 54.5 (38-85) | 56 (35.5-87) | 0.996 (0.987-1.004) | 0.322 | ||
ALT (U/L) | 62 (37-105) | 53 (40-90) | 1.002 (0.995-1.008) | 0.620 | ||
ALT ≥ 2 × ULN at BL | 59.5 (37.5-101) | 54 (40-91.5) | 1.326 (0.597-2.944) | 0.489 | ||
INR | 1.09 (1.05-1.17) | 1.12 (1.09-1.21) | 0.127 (0.001-0.551) | 0.023 | ||
Bilirubin (mg/dl) | 0.85 (0.65-1.16) | 1.02 (0.71-1.52) | 0.903 (0.535-1.525) | 0.703 | ||
Albumin (g/dl) | 3.8 (3.52-4.12) | 3.78 (3.52-4.12) | 2.096 (0.959-4.581) | 0.063 | ||
Creatinine (mg/d) | 0.8 (0.7-1) | 0.81 (0.69-0.93) | 0.327 (0.674-1.585) | 0.165 | ||
Platelet count (10^9/L) | 118 (92-154) | 91 (74-137) | 1.002 (0.996-1.007) | 0.579 | ||
LSM BL (kPa) | 18 (14.6-25.7) | 21.1 (14-38.5) | 0.988 (0.962-1.015) | 0.391 | ||
LSM SVR24 (kPa) | 12.4 (9.4-18) | 17.5 (10.4-32.4) | 0.944 (0.908-0.981) | 0.004 | ||
SSM BL (kPa) | 60.4 (45.7-70.7) | 53.2 (37.4-75) | 1.012 (0.992-1.032) | 0.225 | ||
LSPS BL | 2.17 (1.33-3.77) | 4.15 (1.65-6.26) | 0.817 (0.684-0.975) | 0.025 | ||
LSM decrease (Delta, %) | 33 (18.1–44.6) | 19.4 (0–31.3) | 0.0332 (0.005-0.225) | < 0.0001 | 0.0332 (0.005-0.225) | < 0.0001 |
LSM decrease > 10% (yes) | 54 (90) | 54 (73) | 3.333 (1.242-8.946) | 0.017 | ||
LSM decrease > 20% (yes) | 47 (78.3) | 41 (55.4) | 2.910 (1.352-6.262) | 0.006 |
- Citation: Ravaioli F, Colecchia A, Dajti E, Marasco G, Alemanni LV, Tamè M, Azzaroli F, Brillanti S, Mazzella G, Festi D. Spleen stiffness mirrors changes in portal hypertension after successful interferon-free therapy in chronic-hepatitis C virus patients. World J Hepatol 2018; 10(10): 731-742
- URL: https://www.wjgnet.com/1948-5182/full/v10/i10/731.htm
- DOI: https://dx.doi.org/10.4254/wjh.v10.i10.731