Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance

doi:10.4254/wjh.v10.i10.719

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2018; 10(10): 719-730
Published online Oct 27, 2018. doi: 10.4254/wjh.v10.i10.719

Table 7 Ammonia detoxification capacity (μmol/g wet tissue) for fresh liver microorgans and hepatocyte suspensions used as biological component of the “flat bottom” and cylindrical bio-artificial livers (n = 6 different liver microorgan/hepatocyte preparations in independent runs)

Time (min)	Ammonia detoxification capacity (μmol/g wet tissue)
	Flat bottom BAL	Cylindrical BAL
	LMOs	LMOs	Hepatocytes
60	8.1 ± 1.2^a	ND	12.5 ± 1.8
120	13.2 ± 2.2	ND	18.6 ± 4.9

^aP < 0.05, different from hepatocytes at time 60 min. 128 × 10⁶ hepatocytes = 1 g of liver. ND: Not detectable, means that the total ammonia mass remained equivalent to the 100% of initial dose at the indicated times; LMO: Liver microorgan; BAL: Bio-artificial liver.

Citation: Pizarro MD, Mamprin ME, Daurelio LD, Rodriguez JV, Mediavilla MG. Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance. World J Hepatol 2018; 10(10): 719-730
URL: https://www.wjgnet.com/1948-5182/full/v10/i10/719.htm
DOI: https://dx.doi.org/10.4254/wjh.v10.i10.719