Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance

doi:10.4254/wjh.v10.i10.719

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2018; 10(10): 719-730
Published online Oct 27, 2018. doi: 10.4254/wjh.v10.i10.719

Table 6 Carbamyl phosphate synthetase I and ornithine transcarbamylase enzymatic activity in the cylindrical shaped bio-artificial liver and the Normothermic Reoxygenation System (n = 3 different liver microorgan preparations in independent bio-artificial liver runs/Normothermic Reoxygenation System incubations)

Enzymatic activity		CPSI (U/g wet tissue)			OTC (U/g wet tissue)
Time (min)		0	60	120	0	60	120
Model	Cylindrical BAL	2.48 ± 0.62	2.72 ± 0.61	3.03 ± 0.86	241.7 ± 12.6	235.1 ± 11.9	222.0 ± 23.5
Model	NRS	2.47 ± 0.60	2.82 ± 0.76	3.12 ± 0.73	209.7 ± 33.2	251.8 ± 29.4	228.8 ± 32.8

CPSI: Carbamyl phosphate synthetase I; OTC: Ornithine transcarbamylase; BAL: Bio-artificial liver; NRS: Normothermic Reoxygenation System.

Citation: Pizarro MD, Mamprin ME, Daurelio LD, Rodriguez JV, Mediavilla MG. Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance. World J Hepatol 2018; 10(10): 719-730
URL: https://www.wjgnet.com/1948-5182/full/v10/i10/719.htm
DOI: https://dx.doi.org/10.4254/wjh.v10.i10.719