Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance

doi:10.4254/wjh.v10.i10.719

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2018; 10(10): 719-730
Published online Oct 27, 2018. doi: 10.4254/wjh.v10.i10.719

Table 5 Relative gene expression of Cps1 and Otc for liver microorgans in the cylindrical shaped bio-artificial liver and the Normothermic Reoxygenation System (n = 3 different liver microorgan preparations in independent bio-artificial liver runs/ Normothermic Reoxygenation System incubations)

Relative gene expression		*Cps1*			*Otc*
Time (min)		0	60	120	0	60	120
Model	Cylindrical BAL	1.05 ± 0.17	0.84 ± 0.09	0.63 ± 0.12	1.02 ± 0.26	0.87 ± 0.21	0.67 ± 0.20
Model	NRS	1.00 ± 0.24	0.96 ± 0.12	0.86 ± 0.10	1.00 ± 0.20	0.87 ± 0.16	0.82 ± 0.07

BAL: Bio-artificial liver; NRS: Normothermic Reoxygenation System; Cps1: Carbamyl phosphate synthetase I; Otc: Ornithine transcarbamylase.

Citation: Pizarro MD, Mamprin ME, Daurelio LD, Rodriguez JV, Mediavilla MG. Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance. World J Hepatol 2018; 10(10): 719-730
URL: https://www.wjgnet.com/1948-5182/full/v10/i10/719.htm
DOI: https://dx.doi.org/10.4254/wjh.v10.i10.719