Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance

doi:10.4254/wjh.v10.i10.719

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2018; 10(10): 719-730
Published online Oct 27, 2018. doi: 10.4254/wjh.v10.i10.719

Table 4 Viability and functional parameters evaluated for liver microorgans in the cylindrical shaped bio-artificial liver and the Normothermic Reoxygenation System (n = 6 different liver microorgan preparations in independent bio-artificial liver runs/Normothermic Reoxygenation System incubations)

Evaluated parameters		LDH release (%)			Oxygen Consumption (μmol/min·g wet tissue)
Time (min)		0	60	120	0	60	120
Model	Cylindrical BAL	1.9 ± 0.9	9.4 ± 3.0^a	14.7 ± 3.1^a	1.21 ± 0.24	1.15 ± 0.20	1.16 ± 0.21
Model	NRS	2.6 ± 0.1	8.3 ± 1.2^a	15.5 ± 3.2^a	1.13 ± 0.11	0.85 ± 0.15^c	0.84 ± 0.15^c

^aP < 0.05, different from other times;

^cP < 0.05, different from time 0. BAL: Bio-artificial liver; NRS: Normothermic Reoxygenation System; LDH: Lactate dehydrogenase.

Citation: Pizarro MD, Mamprin ME, Daurelio LD, Rodriguez JV, Mediavilla MG. Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance. World J Hepatol 2018; 10(10): 719-730
URL: https://www.wjgnet.com/1948-5182/full/v10/i10/719.htm
DOI: https://dx.doi.org/10.4254/wjh.v10.i10.719