Era of direct acting anti-viral agents for the treatment of hepatitis C

Table 2 Genotype 1a and 1b infection - treatment-naïve (with compensated cirrhosis) and non-cirrhotic

No.	First line therapy	Alternative regimen
Genotype 1a infection - treatment-naïve and non-cirrhotic
1	Glecaprevir/Pibrentasvir (Mavyret) - 8 wk	Paritaprevir/ritonavir/ombitasvir and dasabuvir (in Viekira Pak and Viekira XR) with weight-based ribavirin - 12 wk
2	Elbasvir/Grazoprevir (Zepatier) for patients without baseline NS5A RAVs for Elbasvir - 12 wk	Simeprevir (Olysio) plus Sofosbuvir (Sovaldi) - 12 wk
3	Ledipasvir/Sofosbuvir (Harvoni) - 12 wk < Ledipasvir/Sofosbuvir (Harvoni) - 8 wk in non-black, HIV-uninfected individuals with serum HCV RNA < 6 million units/mL	Daclatasvir(Daklinza) plus Sofosbuvir (Sovaldi) - 12 wk
4	Sofosbuvir/Velpatasvir (Epclusa) - 12 wk	Elbasvir/Grazoprevir (Zepatier) with weight-based ribavirin for patients with baseline NS5A RAVs for Elbasvir - 16 wk
Genotype 1a infection - treatment-naïve with compensated cirrhosis
1	Glecaprevir/Pibrentasvir (Mavyret) - 12 wk	Elbasvir/Grazoprevir (Zepatier) with weight-based ribavirin for patients with baseline NS5A RASs for Elbasvir - 16 wk
2	Elbasvir/Grazoprevir (Zepatier) for patients without baseline NS5A RAVs for Elbasvir - 12 wk
3	Ledipasvir/Sofosbuvir (Harvoni) - 12 wk
4	Sofosbuvir/Velpatasvir (Epclusa) - 12 wk
Genotype 1b infection - treatment-naïve and non-cirrhotic
1	Glecaprevir/Pibrentasvir (Mavyret) - 8 wk	Paritaprevir/ritonavir/ombitasvir and dasabuvir (in Viekira Pak and Viekira XR) - 12 wk
2	Elbasvir/Grazoprevir (Zepatier) - 12 wk	Simeprevir (Olysio) plus Sofosbuvir (Sovaldi) - 12 wk
3	Ledipasvir/Sofosbuvir (Harvoni) - 12 wk < Ledipasvir/Sofosbuvir (Harvoni - 8 wk in non-black, HIV-uninfected individuals with serum HCV RNA < 6 million units/mL	Daclatasvir (Daklinza) plus Sofosbuvir (Sovaldi) - 12 wk
4	Sofosbuvir/Velpatasvir (Epclusa) - 12 wk
Genotype 1b infection - treatment-naïve with compensated cirrhosis
1	Glecaprevir/Pibrentasvir (Mavyret) - 12 wk	Paritaprevir/ritonavir/ombitasvir and dasabuvir (in Viekira Pak and Viekira XR) - 12 wk
2	Elbasvir/Grazoprevir (Zepatier - 12 wk
3	Ledipasvir/Sofosbuvir (Harvoni) - 12 wk
4	Sofosbuvir/Velpatasvir (Epclusa - 12 wk

RAVs: Resistance- associated variants; HIV: Human immunodeficiency virus; HCV: Hepatitis C virus.